Týp Fakültesi, 28.06.2018, Professor Hélène Girouard

Author: KUSOM
Time: 11:00
Location: ENG 208



Thursday, June 28th, 2018

Speaker         : Professor Hélène Girouard, 
Institut Universitaire de Gériatrie de Montréal, Département de Pharmacologie et Physiologie

Title               : Hypertension And The brain As An End-Organ Target: Is it All about Blood Pressure?

Time              : 11:00 (Refreshments will be served at 10:45)

Place              : ENG 208


Hypertension And The brain As An End-Organ Target: Is it All about Blood Pressure?

Prevalence of hypertension is predicted to substantially increase due to aging and of an increasingly sedentary population. Hypertension is a quiet killer; it can damage organs for years before any symptom develops. The brain is one of the main target organ sensitive to high blood pressure. Indeed, hypertension is the leading risk factor for cognitive dysfunctions, dementia, and stroke. Although the effect of antihypertensive treatments on the incidence of stroke is significant, there is no convincing evidence that lowering blood pressure prevents cognitive impairment and other types of dementia such as Alzheimer’s disease. Furthermore, there are conflicting data as to which antihypertensive drugs should be used for preventing cognitive impairments. Hypertension is an extremely complex condition involving genes, increased arterial stiffness, hormonal disturbances, mechanical stress, increased oxidative stress and inflammation. Consequently, to really understand its impact on the brain, there is a need for a better comprehension of the impact of each component on this organ rather than blood pressure only. In this conference, I will provide an overview of our data in animal models of hypertension and arterial stiffness.