Announcements

CHEMISTRY SEMINAR by Safacan Kölemen

Author: COLLEGE OF SCIENCES
Time: 10:00
Location: ENG 208

KOÇ UNIVERSITY CHEMISTRY SEMINAR

Speaker          : Safacan Kölemen, Department of Chemistry, University of California, Berkeley

Title                : Photodynamic Therapy Of Cancer And Live Cell Imaging

Date                : March 23, 2017, Thursday

Time               : 10:30


Place               : ENG 208

 

Cookie & Tea: ENG 208, 10:15

 

Abstract         : Photodynamic therapy (PDT) is a developing treatment modality for several cancer types. In PDT, therapeutic action is achieved by the generation of cytotoxic singlet oxygen (SO) upon the irradiation of a photosensitizer. In order to generate SO, common strategy is to incorporate heavy atoms on sensitizers. However, presence of heavy atoms increases the dark toxicity, which is not desired in practical applications. Here, we are introducing a new concept for activatable heavy atom free sensitization of PDT by designing novel orthogonal BODIPY-based photosensitizers. Although PDT of cancer has been considered as a promising therapeutic approach for decades, broader acceptance by the medical community and applicability is hampered due to two major reasons; (i) poor penetration depth of the irradiation light and (ii) hypoxic nature of cancer cells. Herein we are also addressing these two everlasting problems of PDT by the use of gold nanoparticles. In the second part of this talk, development of fluorescent molecular probes for synaptic transmission monitoring and copper detection in live cells will be introduced. Synaptic transmission is an essential process for neuronal communication in the nervous system and it takes place at synapses with the help of synaptic vesicles. We are employing pH-sensitive fluorescent molecular probes to image the neurotransmission. On the other hand, copper, as a result of its redox activity plays significant roles in important biological processes. When the redox activity of copper is misregulated, it can also lead to aberrant generation of reactive oxygen species (ROS). Thus development of copper-selective molecular probes with their unique fluorescence output provides a potentially powerful toolbox that allows for the mapping of labile metal pools and the study of the roles of these dynamic fluxes in different applications. Accordingly, we are introducing the design, synthesis, in vitro and in cellulo characterization of a family of three copper probes with varying emission wavelengths from orange to far red.