MBGE SEMINAR by Serkan Kýr

Time: 10:30
Location: SCI 103

Speaker          : Serkan Kir, Ph.D., Dana-Farber Cancer Institute, Harvard Medical School

Title                : Cachexia and brown fat: a burning issue in cancer

Date                : May 23, 2017 Tuesday
Time               : 10:30 A.M.
Cookie & Tea: SCI 103  10:15 A.M.
Place               : SCI 103

Abstract         :   Cachexia is a wasting syndrome associated with elevated basal energy expenditure and loss of adipose tissue and skeletal muscle. About half of all cancer patients suffer from cachexia, which limits cancer therapy and decreases survival and there is currently no effective therapy. Our recent work demonstrated that the tumor-derived factor Parathyroid hormone-related protein (PTHrP) triggers browning of white fat tissue and promotes protein catabolism in skeletal muscle. Circulating PTHrP correlates with a greater degree of cachexia in cancer patients and the neutralization of this factor in tumor-bearing mice blocks adipose tissue browning and wasting and preserves muscle mass and strength. In addition, loss of PTHrP receptor specifically in fat cells also prevents tumor-driven depletion of both fat and muscle tissues, indicating an unexpected crosstalk between the wasting of these two tissues. Future goals include studying PTHrP's role in the fat-muscle connection and developing an anti-PTHrP therapy for use in clinical studies.