PHYSICS SEMINAR by Serap Aksu Ramazanoğlu

Time: 15:00
Location: SCI 103


Speaker          : Serap Aksu Ramazanoğlu

Title                : On-chip Photonic High-throughput Quantitative Bioanalysis
Date                : January 15, 2018 Monday
Time               : 11:00 A.M.
Cookie & Tea: SCI 103 10:45 A.M.
Place               : SCI 103

Abstract         :  Plasmonics enables us to detect biological molecules even in extremely minute amounts using subwavelength light confinement and enhancement near metallic surfaces. Coupled with microfluidics, these detection techniques can lead to powerful methods to quantify molecules in situ and in real time. In this talk I will first present a versatile nanopatterning method for low-cost, high-resolution fabrication of plasmonic biosensors, even on flexible/unconventional substrates. The fabricated biosensors improve the capabilities of conventional vibrational spectroscopy to unprecedented levels. Secondly, I will introduce a novel optofluidic platform to quantify the secretion of cell signaling molecules in a high-throughput manner using the case of single immune cells as an example. These microfluidic devices are based on membrane valve technology and thus are fully automated, and allow measurements in parallel. The quantitative understanding of biological cell signaling using novel materials is fastly integrating in Soft Matter Physics and in the emerging area of Physics of Cancer. More importantly, it provides competent approaches for accurate modeling of immune functions.