Announcements

Seminar In Medicine, 8.11.2018, Prof. Dr. Moses Rodriguez

Author: KUSOM
Time: 17:00
Location: KUH 9th Floor Meeting Room

KOÇ UNIVERSITY

SCHOOL OF MEDICINE

 
SEMINAR IN MEDICINE
Thursday, November 8th,
 2018

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Speaker         : 
Prof. Dr. Moses Rodriguez, Mayo Medical and Graduate Schools of Science, Department of Neurology and Immunology

Title               : From the Discovery to Bedside: Natural Human Monoclonal Antibodies Protect from Neuronal and Axonal Injury in Multiple Sclerosis and Neurodegenerative CNS Diseases  

Time              : 17:00 (Refreshments will be served at 16:30)

Place              : KUH 9th Floor Meeting Room

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FROM THE DISCOVERY TO BEDSIDE: NATURAL HUMAN MONOCLONAL ANTIBODIES PROTECT FROM NEURONAL AND AXONAL INJURY IN MULTIPLE SCLEROSIS AND NEURODEGENERATIVE CNS DISEASES

Our laboratory has discovered a group of natural autoantibodies of germ line DNA sequence which play a major role in myelination and neuronal outgrowth. The antibodies have been sequenced and cloned from both mice and humans. The human antibody rHIgM22 binds to oligodendrocytes and induces remyelination. In contrast human antibody rHIgM12 binds to neurons and induces neuronal extension and guidance. rHIgM22 has completed Phase Ia and Phase Ib clinical trials respectively in 72 MS patients with static neurologic deficits and 30 patients in the midst of a massive acute attacks. In both situations the antibody was found to be safe without any significant side effects. RHIgM12 has been tested in two transgenic models of ALS and showed improved life expectancy in the mice and improved neurologic function. Recently the antibodies have been shown by other scientific groups to induce increase phagocytic function and in newborn mice to induce myelination and neuronal survival. This group of antibodies appears to have physiologic function in the development of the CNS and also appear to have the potential to induce regeneration in patients with a number of neurologic diseases.