CE Seminar by Mirza S. Baig

Author: Collage of Engineering
Time: 11:00
Location: ENG 208






Speaker: Mirza S. Baig, Ph.D.

Title: Regulation of macrophage inflammatory signalling pathways by Neuronal nitric oxide synthase

Date: 11 October 2018

Time: 11:00-12:00

Place: ENG 208

Host: Özlem Keskin




Macrophage plays pivotal roles in pathogen recognition and elimination as well as in the maintenance of tissue homeostasis. Acute inflammatory activation of macrophages by Toll-like and related receptors is characterized by transient activation of AP-1, NF-κB- and IRF-mediated signaling pathways and expression of pro-inflammatory genes. We have investigated the role of Neuronal nitric oxide synthase (NOS1)-mediated regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and Activator protein 1 (AP-1) transcription factors in macrophages as a critical effector of pro-inflammatory cytokine expression. We demonstrate that the low-output nitric oxide (NO) synthase 1 (NOS1) plays a critical role in the inflammatory response by promoting the activity of NF-κB and AP1 transcription factors. Specifically, NOS1-derived NO production in macrophages leads to the proteolysis of suppressor of cytokine signaling 1 (SOCS1), alleviating its repression of NF-κB and AP1 transcriptional activity and increase of proinflammatory cytokine expression. Taken together, our results demonstrate that NOS1 is a fundamental regulator of gene transcription of the inflammatory response thereby heavily impacting the course, type and duration of the inflammatory process.



Mirza is currently serving as an Assistant Professor at the reputed Indian Institute of Technology (IIT). He earned his PhD in Biochemistry from Central Drug Research Institute (CDRI)-Jawaharlal Nehru University (JNU), New Delhi in 2008. As a Postdoctoral scientist at the University of Illinois at Chicago (UIC), USA, he worked on molecular signaling of inflammation. Later, he received an offer from the world-class Mayo Clinic, Rochester, USA for a research scientist position. Mirza has been honored with various international awards. He has published several research articles in high impact journals- The Journal of Experimental Medicine (JEM), Scientific Reports, Oncotargets, and J Allergy Clin Immunol.