Announcements

Seminar In Medicine, 18.12.2018, Doç. Dr. Emek Kocatürk Göncü

Author: KUSOM
Time: 14:00
Location: MED 176

KOÇ UNIVERSITY

SCHOOL OF MEDICINE

 
SEMINAR IN MEDICINE
Tuesday, December 18th,
 2018

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Speaker         : Doç. Dr. Emek Kocatürk Göncü, Okmeydanı Training and Research Hospital, Department of Dermatology

Title               : Chronic Urticaria: Current and Future Perspectives

Time              : 14.00 (Refreshments will be served at 13:45)

Place              : MED 176

TelePresence   : AH 5th floor Chief Medical Officer / KUH 9th floor Meeting Room

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CHRONIC URTICARIA: CURRENT AND FUTURE PERSPECTIVES

  Chronic urticaria is a systemic disease characterized by the sudden appearance of wheals and/or angioedema for longer than six weeks. It is classified into spontaneous and inducible forms where in the latter an eliciting  trigger such as cold, heat or pressure is required for the symptoms to occur. Mast cells are the major actors of the disease but the exact pathomechanism why the mast cell releseability is increased remains to be defined. Autoimmunity accounts for half of the cases; other factors to be accused are chronic infections, intolerance and stress. Autoimmune disorders such as autoimmune thyroid diseases and pscyhiatric conditions often comorbid with chronic urticaria. Management depends on avoidance of triggering factors, treatment of comorbid conditions and pharmacological treatment. The mainstay of pharmacological treatment are the H1-antihistamines which are increased up to fourfold in resistant cases. In antihistamine refractory cases, anti-IgE treatment, omalizumab is recommended. Precision medicine will be guiding the future of chronic urticaria treatment where biomarkers for treatment responses are available. Some of the future treatments on development are new anti-IgE and anti-IL-5 treatments.