MBGE SEMINAR by Tadahiro Goda

Time: 11:00
Location: SCI 103

Speaker          :
Tadahiro Goda, Ph.D, Research Associate of Pediatric Ophthalmology, Cincinnati Children’s Hospital Medical Center

Title                : Circadian rhythms of body temperature in Drosophila and mouse

Date                : February 15, 2019, Friday
Time               : 11:00   
Cookie & Tea: 10:45 SCI 103 
Place               : SCI 103  

Abstract         :

Our body temperatures exhibit 24-hour fluctuations, which is regulated by a biological time-keeping system, circadian clock. This body temperature rhythm is associated with other daily cycles of physiological activities including sleep-wake cycles and metabolism. However, the regulatory mechanisms of body temperature rhythm are still largely unclear. A fruit fly, Drosophila melanogaster, is ectotherm and their body temperatures are very close to their surrounding temperatures. We discovered that Drosophila shows the body temperature rhythm by selecting different temperature locations in a day, named temperature preference rhythm (TPR). Drosophila provides a powerful model system for biological research due to its abundant genetic tools and a relatively simple nervous system.  Therefore, we aimed to dissect the regulatory mechanisms in body temperature rhythm using Drosophila. We identified that Drosophila diuretic hormone 31 (DH31) and its receptor (DH31R) regulate TPR. Surprisingly, we found that mammalian homolog of DH31R, calcitonin receptor, also regulate body temperature rhythm in mice. Furthermore, we demonstrated that neither DH31R nor calcitonin receptor was involved in the other circadian clock output, locomotor activity rhythm. Taken together, these data suggest that the regulatory mechanisms of body temperature rhythm could evolutionally be conserved between flies and mammals, and our research would contribute to understanding the human body temperature rhythm in the future.