Announcements

Join Zoom Meeting-MBGE SEMINAR by Aytu­ Tunšel

Author: COLLEGE OF SCIENCES
Time: 12:00
Location: Zoom meeting

KOÇ UNIVERSITY MBGE SEMINAR

****************************

Speaker          : Aytu­ Tunçel,  Postdoctoral scholar at University of Tennessee

Title                 : Understanding starch biosynthesis and engineering novel glucans in crops

Date                : Thursday, November 26, 2020

Time                : 12:00-13:00

Zoom info      : Join Zoom Meeting

https://kocun.zoom.us/j/97886723711

Meeting ID: 978 8672 3711
Passcode: 280354

   

Abstract:    

Starch, the second most abundant organic compound on earth and the main form of energy storage in plants, supplies more than half of the caloric intake in our daily diet. Significant improvements in crop productivity are required to feed an ever-increasing world population and to offset dwindling arable lands due to the deteriorating climate change. Likewise, engineering plants with healthier carbohydrates for human consumption is needed to tackle with silent pandemics such as diabetes, inflammatory and autoimmune disorders. Therefore, understanding starch biosynthesis and its regulation is crucial for engineering the desired traits into crops to boost yield and quality. Extensive efforts to increase starch yield have focused on ADPglucose pyrophosphorylase (AGPase) owing to its pivotal role of catalysing the rate limiting step in starch biosynthesis. In this seminar, I will describe how our mutational and biochemical studies revealed that starch biosynthesis during rice endosperm development in seeds is controlled predominantly by the catalytic activity of the cytoplasmic AGPase and elucidate the functions of large and small subunits of the enzyme in its activity, allosteric regulation and redox response. Moreover, I will illustrate how we can create commercially and nutritionally valuable, transgene free potatoes containing digestion resistant starch, a more complex carbohydrate with lower glycaemic index, using synthetic biology tools and crispr/cas9 mediated multiplex genome editing of the starch branching enzymes. Furthermore, I will introduce new ideas to advance our understanding of the AGPase structure-function relationship and its role in starch metabolism, and present novel genome editing approaches to enhance starch yield.