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Join Zoom Meeting-MBGE SEMINAR by Murat Acar

Author: COLLEGE OF SCIENCES
Time: 08:30
Location: Zoom meeting

KOÇ UNIVERSITY MBGE SEMINAR

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Speaker          : Assoc. Prof.Murat Acar, Yale University, Department of Molecular Cellular and Developmental Biology,

 Department of Physics, Yale Systems Biology Institute

Title                 : Systems Biology of Single-Cell Aging: from Gene Expression and Noise Dynamics to Lifespan Extension

Date                : Wednesday, April 14, 2021

Time                  : 08:30-09:30

Zoom info      : Join Zoom Meeting

https://kocun.zoom.us/j/97846000531

 

Meeting ID: 978 4600 0531
Passcode:
082302

   

Abstract:    

Aging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its effects has been hampered by an incomplete understanding of aging at the single-cell level. With recently developed techniques for performing genetic and phenotypic characterizations at single-cell resolution, comprehensive monitoring of time-dependent changes occurring in individual aging cells is now possible. Single-cell-level experimentation can elucidate key biological insights about cellular aging that are masked in population-level studies. In this talk,I will describe how microfluidic devices can automate the microscopic monitoring of yeast cells throughout their entire replicative lifespan (RLS). I will show how gene expression and noise dynamically change in a generation-specific manner during cellular aging. Further, I will talk about a novel compound-screening technology that we developed to discover chemical compounds with RLS-extension effects and show results from its application to FDA-approved drug libraries.