Announcements

Seminer in Medicine / Dr. Hülya Seymen

Author: KUSOM
Time: 14:00
Location: https://kocun.zoom.us/j/96391619828

KOÇ UNIVERSITY

SCHOOL OF MEDICINE

  

SEMINAR IN MEDICINE
Friday, May 7th, 2021

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Speaker:                Dr. Hülya Seymen – Department of Nuclear Medicine and Molecular Imaging, Koç University Hospital

Title:                      FAPI-Radioligands: A New Oncologic Approach

Time:                     14:00

Zoom:                   https://kocun.zoom.us/j/98257907086

Meeting ID:             982 5790 7086

Passcode:            221965

 

FAPI-RADIOLIGANDS: A NEW ONCOLOGIC APPROACH

 Fibroblast activation protein (FAP), expressed by cancer associated fibroblasts, which can be detected in a variety of malignant tumors, is able to activate cell signaling and contributes to tumor cell migration, tumor cell invasion, and tumor angiogenesis. Based on a quinoline-based FAP-specific inhibitor (FAPI), a new class of radiopharmaceuticals was designed.

 68Ga-FAPI PET/CT is a promising new diagnostic method for imaging various kinds of cancer, in particular pancreatic, head and neck, colon, lung, and breast cancer, with tumor-to-background contrast ratios equal to or even better than those of 18F-FDG. FAP-targeted radiolabeled probes will contribute to the management of cancer patients. FAPI can play a role in the diagnostic imaging of some cancers for which FDG is known to have limited value. 68Ga-FAPI tracers contain the universal DOTA-chelator, a theranostic approach—after labeling the ligand with an appropriate therapeutic radionuclide—also seems feasible. 68Ga-FAPI imaging might be helpful for local therapies such as stereotactic body radiotherapy by improving accuracy.

 Consequently, we are now increasingly using this tracer to amend the diagnostics of cancer patients who are facing the limitations of standard examinations.